Impaired Cholera Toxin Relaxation With Age in Rat Aorta

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Impaired cholera toxin relaxation with age in rat aorta.

Beta-adrenergic-mediated vasorelaxation declines with maturation and aging. Available data suggest that impaired stimulatory G-protein function could explain this deficit. We have previously found a loss of cholera toxin (CT)-stimulated adenosine diphosphate (ADP) ribosylation with age in rat aortic membrane preparations, without evidence for loss of the stimulatory alpha subunit of G protein (...

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Saffron Induced Relaxation in Isolated Rat Aorta via Endothelium Dependent and Independent Mechanisms

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Saffron Induced Relaxation in Isolated Rat Aorta via Endothelium Dependent and Independent Mechanisms

Crocus sativus L. (saffron) is a widely used food additive for its color and taste. The hypotensive effects of saffron have been shown in previous studies. The aim of this study was to evaluate the mechanism of vasodilatory effects induced by saffron on isolated rat aorta.To study the vasodilatory effects of saffron aqueous extract (0.5, 1 and 2 mg/mL), isolated rat thoracic aorta rings were co...

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Cholera Toxin

Vibrio cholerae, the causative agent of cholera, requires two coordinately regulated factors for full virulence: cholera toxin (CT), a potent enterotoxin, and toxin-coregulated pili (TCP), surface organelles required for intestinal colonization. The structural genes for CT are shown here to be encoded by a filamentous bacteriophage (designated CTXCP), which is related to coliphage Ml 3. The CTX...

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ژورنال

عنوان ژورنال: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

سال: 1999

ISSN: 1079-5006,1758-535X

DOI: 10.1093/gerona/54.4.b154